I ride 48:16 on my commuter which is 26″ wheel so a 78″ gear.
Pros are that I can sit comfortably at 20mph on the flat bits. It also improves my climbing ability and strength.
Cons are that it is flippin hard work to get it up hills. Normally it’s fine but doesn’t allow for days when you’re tired or the weather is bad. It’s virtually unrideable in snowy weather as it spins the back wheel.
Other big disadvantage is pulling away from lights as you need to put in a lot of effort to get up to speed.
I find it fine, I have the option to go to 18 or 20 on the back during winter.
So 50 on the front would be ok as you could all the way up to 20t on the rear to find a suitable gear.