Eastpack looks great. Generally thiefthrow proof too.
I’d usually be away 5 days a week when I flew LOTS. I gave up with carry on stuff as it was just too much hassle & instead adopted the “Oh Delta you lost my bags? Again? How sad, here’s another bill from the Vans / Oakley / Fox store.” approach.
Standard travelling kit ended up being a 70L Mountain Equipment duffle and Crumpler Cheesy Disco courier. Both were strong, dependable, distinctive and most importantly I could run with them, launch myself through ticket barriers, use the duffle as a bench, table or pillow. The Crumpler even withstood being strapped to the back of my KTM through some atrocious weather.