my commuter bike (a cross bike that was really designed as a gravel bike 10 years + before they ‘invented’ gravel bikes – but now mostly dorbed in the rear rack and guards) I’ll be jumping on in a minute has:-
GRX 800 chainset (46/30) and front mech
105 11spd rear mech
105 10spd TRIPLE shifters
Miche 10spd cassette (12-28)
The front mech and shifter are set up using the middle and top ring positions on the STI and works fine. The miche cassette has a couple of snickerty sprockets that are annoying the hell out of me and might get sacked off but I think that might be a poorly timed chain change that is too new for the life left in the cassette.
It works fine with a 11-32 cassette too but I don’t need the range on the road. I think a 11-36 could probably be got away with too but tbh 10spd options are a bit more limited and I don’t plan to upgrade the STIs until they die.