ADvantages don't have particularly tough sidewalls but they are very good all round tyres with good grip at any lean angle but can break away at high lean and clog up in mud. High rollers are tougher and also good, especially for wetter and looser conditions, but have a gap in grip until leant over. I use both but don't ride tires as skinny as 2.1 (14.5st and don't like having to run the high pressures I need for skinnier tyres), and certainly not the HR as they size up small anyway. Any Maxxis tyre harder than 60a on the front get a bit too exciting on anything other than bone dry track for my tastes.
ADvantage 2.25s are light, fast rolling and all the knobs stay attached so why not go for them? If you want a faster rolling set up try a Crossmark 2.25 60a rear ADvantage 2.25 60a front. Comfy, fast and goes around corners.
All my own opinions, your experience may differ!