I do it all the time, and whilst towing a caravan!
Top to tail is essential, for us, and it also helps massively to change the handedness of the racks that you want to put on the other side otherwise you’ll have a right ballache getting bikes on. But because some are backwards you’ll have to really think about which ones you want to flip because mounting some backwards will also flip the handedness. So figure it out and then number each rack to make it easier next time!
Also, if you are buying new, make sure you spec them all with the same key!
And fuel consumption is not hit that hard at all in my experience.
Big hit, for me in my Passat. I go from about 60 unladen to about 52 just with a roof rack on and no bikes at all. Bikes on it’s low-mid 40s so it’s at least a 25% hit.
Re noise, my Thule racks do whistle a bit.