Using them is just as easy as clinchers…
Fitting, repairing and replacing them is more faff, not difficult, just time consuming. If you go to your bike and you have a flat tub you’ll most likely want to use a different wheel, not change it before you nip out!
Saying that you can carry spares and change them roadside to get you home, and worry about a proper glue job etc at a later date.
IMO there’s little point unless you’re looking at carbon wheelsets, as there is a pretty substantial weight penalty associated with using clinchers on top end wheelsets.
Edit: damn your edit clarifying what you meant!
The tyres themselves won’t make a massive difference, but if you’re on 1600g 23mm deep clinchers and you change to 1200g 50mm deep tubs you will see a difference. As part of that you gain tubs, but that’s not really where the big advantage comes IMO. Were you to change to 1600g 23mm tub wheels I’m not sure you’d see much (if any) real improvement.
If someone could make 1000g clincher wheelsets for £400 I’d choose those, as clinchers are undeniably less faff, but they can’t, so it’s tubs!