Loaded or not, there’s a noticeable difference in QR and 15/20mm forks.
Frame I’m not so sure about. Possibly makes a difference if you’re really pushing the handling.
If you’re going for a different frame anyway then you might want to consider Boost in which case you’ll be going through-axle by default.
Sorry if this sounds vacant, but do you have to pair a boost hub with a boost fork / frame?
Only reason I ask is that the Shutter Precision PD-8X dynamo hub is 100mm / 15mm
My motivation for the frame is that my cube carbon has been a real pain as there rear QR has to be tightened really tightly, otherwise, it makes a noise when I am out of the saddle pedaling hard. Tightening up the wheel tightly has now made the inside edge of the frame aluminium dimpled from the knurled face of the wheel (hope that makes sense) as a result I have to keep readjusting the disc brake caliper so as to recenter it.