Cycling, round or oval rings, is the very definition of constantly changing ‘resistance’ (assume you mean torque).
Yes, except for me oval made that worse. Oval creates additional changes in resistance and cadence resulting in a kind of rhythmic successive knee impact/strain through the crank rotation. As the miles rack up so that begins to build into a knee issue. Once leg muscles have gotten used to the way ovals work I think any benefit is lost, even making it harder as the leg eventually weakens from not powering evenly through the top and bottom of the stroke. I imagine all of this depends on the individual rider’s pedalling style.
There have been a few threads on here over the years where people have reported oval chainrings causing knee issues or making it worse. Probably some where it’s explained better than I am doing here. Also some where the opposite is reported.