Nothing is bulletproof – I’ve had punctures with Marathons and Gatorskins.
Other than a solid tyre no but Marathon Plus come very close. I used them for a few years on road and off road and the gravel is very flinty where I ride and when using lighter tyres sometimes saw a puncture every few weeks. Had absolutely none with the Marathon Plus to the point I didn’t spares (partly because I probably could not have got the tyre back on anyway!)
For road commute I would just use a Durano Plus and probably overkill but I would rather have a slightly less comfortable ride than fix a puncture. Even felt that wight when leisure cycling with Marathon Plus as I really can’t be bothered with punctures when cycling.
