From what I know of the Ti 456 (I think I might’ve been the first person to break one – luckily at the back end not the head tube, unluckily after having it for about 2 months) and Ti in general (I work as an engineer…), I think the problem is twofold.
1) The bike companies hype up the durability of ti frames – so people expect the frames to last as long as the hype says.
2) The bike designers maybe believe the hype a bit too much themselves and push things a bit too far when speccing Ti frame tubes etc.
As above, Ti frames can last a very long time, but so can a well made steel, aluminium or carbon frame. And it mostly depends how well designed and built they are, not on the theoretical benefits of any of the materials.
To be fair to On-One, none of the other stuff of theirs I have has broken (over a much longer period of time than I ever had the Ti 456), and that includes 2 steel frames, carbon forks and a fair few aluminium bits. They did also replace the frame quickly under warranty. I’d definately buy something not made of Ti from them again.
From other people I know who’ve owned a variety of Ti frames, they seem no more likely to last you for life than anything else.