As Graham S says, manual is often the only option. I’m just back from shooting a foster kids’ do – each pic had a kid shaking hands with Chris Cook (Olympic swimming chappie) and getting a certificate.
I wanted every single exposure (all 72 of them) to be exactly the same, so I don’t need to spend hours on the computer later. It also gives a nice uniformity to a set of images and there is less to go wrong.
So I set up my remote flash, camera in manual mode, apperture set to f2.8 and shutter speed to 1/200th. White balance set to flash too (usually I just leave it on auto).
Now it doesn’t matter if someone switches lights on or off, or if the sun goes down or anything else really, as I am controlling the amount of light hitting the subject with the flash and camera settings.
The camera’s almost always on apperture priority for weddings though, unless I’m messing about with flash, in which case it’s likely to be on shutter prioity.