Huh, good question actually, I’ve just replaced some 20mm internal DT wheels with the same Ultegra wheels, guess I’m going to find out soon enough!
One thing I’d say is that my first impressions of the 20mm internal DT wheels when I fitted them 3 years ago was that the tyre felt less compliant, rather than more. Took a bit of fiddling with tubes, pressures and seatpost to figure it out.
Also my summer bike has 17mm internal Fulcrums, and I can honestly say I’ve never noticed a difference switching between bikes (both aluminium frames, arguably the summer bike might be more compliant as it has noticebaly skinnier stays, plus summer bike has nicer tyres). I suspect you’ll notice a slight difference initially but adjust pretty quickly. personally I’d just concentrate on fitting the widest tyre I could in there and being done with it, wasn’t long ago we were running 2.3″ MTB tyres tubeless on 17mm internal rims…