MX80 11-50: largest two sprockets are alloy, compared to just the biggest on the 11-46 MX8. Also, more cogs mounted on two spiders, with separate cogs spaced with metal spacers. The MS8 is all steel, only one spider (IIRC), and more separate cogs spaced with plastic spacers. I’ve had/have all three. The latter caused quite a bit of scoring on my (steel) freehub and didn’t shift as well as the MX8/80, which was a pity as I liked the durability implications of the all-steel sprocket combo. Very happy with the MX8 11-46 that currently has over 3500km on it on my hardtail, but wouldn’t buy an MS8 again. Don’t have enough miles on the MX80 yet to comment.