It is important.
The derailleur has a slightly bent and offset cage which helps with chain angles and relies on a 55mm chainline.
In any case, if you purchase a full T-Type groupset you have no choice. The chainset comes with a longer DUB Wide crankset spindle and spacers out of the box which is 55mm by design.
Your frame can’t ‘be 52mm’ as such. It has a standard width BB and standard rear spacing. It is the groupset (or more specifically the chainset) that really defines the chainline. Some bikes (my Yeti ARC as an example) require a 55mm chainline because the chain stays are spaced quite wide, so maybe the Hope 52mm thing might just be a statement that it doesn’t need wider spaced cranks to clear the stays.
I am considering an Atherton and whilst the 150 and 130 both have a UDH, only the 130 will accept Transmission, with no plans for the 150 according to the conversation that I have had. It is (as somebody else has rightly pointed out) not a given than all UDH bikes will accept Transmission.
I have Transmission on a couple of bikes and if you can fit it, you won’t regret it. It’s definitely next gen stuff.