The quick release fixing bracket used holds the bag forward of the handlebar by appox. 7cm so cables shouldn’t be an issue. I found that the bracket really wants to be fitted and left in situ as its a cable clamped by a bolt to hold it tight, if you keep taking it on & off the cable may deteriorate. Great bags & system, the new ones require that you buy the bracket separately. https://www.cyclestore.co.uk/ are good for a bargain. The Achilles heel of the Ortileb handle bar bag is fitting a front light, I use a be seen light on my fork leg with a stub, but in winter i’d need to use a seeing light on the handlebar which the bag doesn’t allow for, Ortileb make an bracket for this but it wobbles a lot with road vibration causing juddering of the light beam and I get glare off the bag top which kills my night vision.
I have an Ortileb handle bar bag, i was eyeing up a https://www.topeak.com/global/en/products/189-Handlebar-Bags/1301-BARLOADER which looks great but i think it would have interfered with my MTB style brake cables.
