I’ve never got on with multi effects. I’m not a great pedal user, but I prefer the immediacy of a pedal with knobs than using a menu based preset system. The major problem I’ve found is that you need different FX settings for different amp settings, so unless you always use the same amp with the same settings, you end up having to be very organised with your presets to keep the two in sync. It’s also only the more expensive fx which allow some effects to be used at the front end of the amp, and delay / reverb in the fx loop.
I’m using a Joyo tremolo and Boss DD-20 at the moment, which is probably about as complicated as I can stand ;-). Happy with both pedals….the DD-20 is ace….really easy to use looper and delay at the same time.