If you have a reserve and tell people what the reserve is then thats just the same as setting the starting price as the lowest price you'll accept, so why not just to that? When I'm bidding and sensible bids are being made and the reserve is still not being met I just look elsewhere, it tells me that the bidder doesn't actually want to sell.
When selling I never bother with reserves, but I also don't do 99p starting prices if it would do me harm for an item to sell too cheaply. You need two serious people bidding to get a good price, if you've only got one then your stuffed. I've never had a problem with items with a reasonable starting price either not selling, or them not being fought over, just be sure that the price is the very least you can afford to let it go for and people will bid it up higher than if you set the start too high.