I have heard of people modifying the cable stops to accept a full outer instead of an inner (no links, just talking to bike nuts).
Problems with drilling you ally frame: Smaller holes induce larger stress concentrations (read: more likely to crack the frame) but a larger hole is giving you a lot less material (read: shit gona snap slowly).
The places that you would be likely to drill i.e. near the welds, would be where the stresses are greatest anyway so would be a super bad idea and would likely cause catastrophic failure.
Not to mention possible heating (tempering different bits at different rates) and your drill slipping as you would be drilling at an angle.
Also it would completely void any warranty you have with the manufacturer.
Unless you have done some FEA and calculations on the best position to drill, I wouldn’t touch it and I’ve re-welded ally frames (with varying successes).