I have been through this process, but with a view to using both my old non-boost 29 and new 27.5+ wheels on the bike.
The advantage of using non-boost hubs with adapters is interchangeability with non-boost frames (though if you are going for wide rims, that will only work if your non-boost frame/fork takes plus tyres). If you go for the “keep the wheel in the middle and use a slim 6-bolt disc adapter” type of spacer set then you can use your wheels on a standard frame/fork just by removing the disc adapter. But, you will have a non-boost chainline on your boost frame, which may or may not work depending on how fat your plus tyres are, whether you go for a boost crankset etc. I am sure it can be done though.
If you choose the “space it all over one side” type, you will need to re-dish (and remove the adapter on the rear) to use on a non-boost frame. I chose this, I sacrificed wheel interchangeability with my non-boost 29er frame, but will get interchangeability with a boost width 27.5+ wheelset when I get round to building one.
Unless your spoke lengths are at the limit one way or another, there should be enough thread to re-dish – there was on my wheels, it is only a couple of turns.