Chainline plus b tension.
Bear with me. I’m running GX1 on 1×11 32t up front 42-10 at the back. But with a slightly compromised chainline due to using the Hope boost adapters.
It only JUST works. If the limits are correct and the tension good, there is about 1/4 turn of the b-tension where it will work. Add tension at that point and the chain will not drop, at all. Any less and it fouls it slightly so it won’t shift onto the big sprocket. It also needs the pivots of the mech to be well lubed so nothing impedes it.
12 speed is more of a faff still and is, I believe, right at the limit of what is practical for a normal Joe Public rider in terms of:
1. Time available to set things up perfectly.
2. Getting it covered in mud.
3. Money to keep replacing chains to keep it working.
If someone would bring out a 9 speed that did something like 46-11, I’d buy it like a shot.