Northern Quarter for drinks on Saturday eve. Couple of quid in a taxi, bit of a faff to walk to if you don't know the area.
Felicini on Oxford Rd does good Italian food.
Cask on Liverpool Road - proper ales, about 3 mins walk from the Hilton.
There's a really good Tapas bar, about half way down Deansgate - can't remember the name, good for a late lunch.
War museum north is different- good building, you could do this with a trip up the Ship Canal.. and combine this with a tour around Old Trafford!
Urbis would have been good for a few hours, but it's shut currently. Trip on the Manchester eye...
2nd for Akbars / East is East for curry.