I was getting some wrist pain when riding my bike last year which I suspected was down to poor hand/wrist posture from not having enough core strength to properly support the weight of my torso. I fitted some Large GA3 grips which have got just enough of a palm wing to force me to position my wrists properly which has largely resolved the issue (though it probably would be better for me to build up my core strength in the longer term).
Apart from the shape of the grips helping posture (and the large size wich is a nice fit for my bigger paws) they do also seem to be made to pretty high standard with a nice grippy rubber that isn’t wearing too quickly. The single ended clamps also seem to be working well too and I’ve not had any movement despite my considerable bulk being swung about on them.
EDIT:
This is what I was doing to my wrists and how the grips shifted them about. According to Ergon this is linked to issues with the Carpal Tunnel syndrome/median nerve damage