IMO it's best to have the heating on when you're in and off when you're out. Takes less energy to heat the house back up to the required temperature than to maintain that temperature. Think of a kettle – you boil water when you need it. You don't keep the kettle boiling for a few hours in between.
Not sure about the boiler temp, might depend on the hot water/central heating system. My boiler provides both hot water and heating. I have the boiler set to high, hot water tank thermostats high enough to just get the amount of hot water I need, TRV's on all radiators except lounge where the room thermostat (16 degrees) is. Timer set for 1 hour in the morning and 6 hours in the evening.
No figures to back this up but my theory is. With the boiler set to high then the hot water cyclinder heats up quicker and then the radiators heat up quicker than if the boiler was set to low. Therefore the boiler is on for a shorter period of time. In winter, the boiler will kick in when the timer turns on, heats up the water/house and then may come on late evening if it's very cold or if I run hot water off.
But, maybe there is a limit as to how high I should run the boiler? But the reality is to save money you should run the house at a "man's temperature" rather than "tropical hot house" 😯