Firstly, space flight is intrinsically dangerous. The energies involved see to that (Massive potential energy, exchanged over only a couple of minutes for massive kinetic energy!) So any serious failure is almost certainly going to result in significant injuries, death and destruction. No matter what technology is being used, that is the case, and with our current understanding of physics, it always will be. Interestingly, it’s telling that as far as have been reported, no-one has actually died in Space itself! (the complicated bit with getting to space is the first approx 50km!)
Take the Space shuttle, still probably the single most complicated machine every built by man. It flew 134 times, and failed twice, so that’s a 1 in 67 probability of catastrophic failure. If you said “you wanna fly it tomorrow?” I’d bite your hand off for the chance!!