I used to get all sorts of knee and ankle pain when running, so gave up as a bad job…
Then I moved somewhere which allowed me to run mostly off road, plus I trained myself to fore/mid-foot strike, instead of landing on my heel, which my wife lovingly described as me looking like a demented antelope prancing along!
No idea which had the greatest benefit, but since doing those I’ve not had any of my previous issues.
I also noticed that you don’t get any of the support type language around buying trail running shoes, that seems to be more about ‘drop’ these days! I always assumed that was because on the road your foot is always landing the same way every stride and so you are getting very similar repeated stresses and strains over a whole run… whereas in trail running your foot is landing differently all the time, so the impact on you foot/ankle is different for pretty much every stride…
Anyway, I now just buying trail running shoes which are comfortable to run in… and having moved to Altra’s, with their wide toe box, I think they have ruined more normal running shoes for me!!