I prefer south to north. I think the climbs and the descents are more interesting that way.
Basically you can start in Skipton, ride to Kirkby Stephen then catch the Carlisle/Settle line back to Skipton, although a close eye on the timetable is needed on Sundays. If that’s too far, you could go from Settle.
My route from Skipton would be over Sharp Haw, Hetton, Weets Top, Calton descent, up for lunch in Malham, climb out to the top of Stockdale Lane, down Stockdale, cheeky past Victoria Cave, down into Stainforth, road into Crummackdale, up over into Clapham for overnight. Then follow PBW from there up Long Lane etc.
You could feasibly make a three-dayer out of it.