As someone who has run Leftys on a couple of non Cannondale bikes over the years the proper adapters are the way to go. I have 2 of the Lefty 4 All adapters and a Project 321 steerer. With both of these you get a ful suite of clamp adapters.
You need the lower “piece” of the proper adapters for the lower clamp to clamp to – there is then a mild bulge for the crown race. The only time I’ve run one tapered was on a internal lower bearing arrangement otherwise you often end up with a too larger space between the clamps.
For a 44mm HT 2 1/18” internal (IS41?) cups work best with the correct steerer.
I really like the Lefty but dependant upon which version you have depends how fanickity they are – e.g. bearing resets.
Often not a cheap experiment but a fun one!
This was 2012ish on a tapered HT: