I have ISM ones on all my bikes, PL version on road and gravel, PM on mtb. I swopped over to them after much research around 10 yrs ago when going through prostate cancer surgery and rehab onto the bike. I got so used to the comfort of them I have stuck with them. The ISM website is really good and has fitting instructions that you need to follow to the letter – the saddle goes a bit further back and lower than your regular one in general.
They are expensive to buy, some shops may give you a trial but not many physical places stock them. I have a couple spare used ones and would be happy to send you one to try ? I have both the road and mtb ones in my spares box so could send you either. PM me if interested.
Cheers