Palm Springs is an easy drive from SD or LA. Turning it into a triangle adding Orange County would be a fun loop. JT around 40-60 mins from Palm Springs, both of which are fantastic.
the other thing I’d reccomend is flying in and out of different places, with open jaw flights and a 1-way car rental. Not the absolute cheapest way of doing things, but flights are often roughly the same price as a return and 1-way car rental from one of the big players (avis et al) can be as little as a tenner more than returning to the same place. Saves a lot of time if you’re thinking of a large itinerary
Kayak does a ‘nearby’ locations checkbox for car rental search too. I went 40km out of San Diego in a Uber to Carlsbad and saved $800 in car rental from one of the majors. Tiddy airport too so in and out in no time, dropped off in down town San Francisco