[Closed] PSA: Horizon tonight about exercise

I didn't get the 'non-responder' bit, does that mean hat for some people, doing any exersize at all, won't make any difference? that can't be right, can it?

I'd read that as non-responders to the exercise programme and indicators being used...

He did respond to the insulin indicator, just didn't increase total aerobic capacity in the VO2max test. He was able to maintain effort for longer in that test - which I would say is a valid "fitness" response

I didn't get the 'non-responder' bit

I think it means that your potential to increase the VO2 part of your fitness is genetically determined, other aspects will be improved by the right type of exercise....

I was just confused by it all, I didn't get the 'non-responder' bit, does that mean hat for some people, doing any exersize at all, won't make any difference?

No, it jsut means you won't increase your VO2 max. You can increase all kinds of other things that will make you 'fitter'.

No TV for me, but I've just hit it up on the iplayer.

The blood fat thing.
Was the chap in the lab suggesting that there was less fat in the presenter's blood as a function of the long walk he had the evening before.
And that this was due to the process of his body replenishing the glycogen store in his nuscles ?.

Also, they seemed to be saying that fat in your blood is a bad thing, but we need fat in our blood.

Double post, sorry.

I didn't get the 'non-responder' bit, does that mean hat for some people, doing any exersize at all, won't make any difference? that can't be right, can it?

I think the reasons are probably fairly complex, but one of the problems of using VO2max as a measurement is that it's often mistaken as a limitation of potential fitness. So a fast cyclist will tend to have a higher vo2max than a slower one. What it doesn't tell you is if the limitation on that figure is from you heart and lungs, or from lack of muscle recruitment to exploit those hearts and lungs. So for instance Chris Hoy who can ride far far faster than me will have a higher VO2max. But the reason he can ride faster is not that he has a higher VO2max, but that he has a lot more muscle which produces a lot more speed. That muscle needs more oxygen, hence he has a higher VO2max.

That doesn't really answer your question though, cos I don't know the answer 🙂

However if you google

heritage research vo2max

Somewhere hopefully the answer about the non-responders is addressed.

The blood fat thing.
Was the chap in the lab suggesting that there was less fat in the presenter's blood as a function of the long walk he had the evening before.

Yes.

And that this was due to the process of his body replenishing the glycogen store in his nuscles ?.

No. The glycogen thing was related to the blood sugar and insulin response. If you use the glycogen stored in your muscles, the muscles will pull sugar from your blodstream to replace it.

The blood fat was to do with an enzyme produced during light exercise.

I took the non-responder to mean that he did not gain any fitness benefit, using VO2 max as an indicator to doing just the HIIT. I would think he would see a benefit by having a varied training program including a variety of different intensities.

I just took the non-responder thing to describe the people whom during the test, didn't, err, show any significant response or [i]imporvement[/i] to the exercise they were undertaking.

I certainly feel like a non-responder.
In that I never seem to improve.
But then, I don't measure / monitor myself.

[i]The blood fat was to do with an enzyme produced during light exercise.[/i]

Ah, yes, I remember that now.
Lipase

Ta.

😉

Was the chap in the lab suggesting that there was less fat in the presenter's blood as a function of the long walk he had the evening before.

Yes, I think so - all a bit jumbled though with vague references to DNA to "sex it up" a bit....

.....something to do with lipase induction so more of the Scottish breakfast was used to replenish glycogen than would be without the evening exercise.

Could always try eating something a bit more healthy though - that breakfast really looked J Arthur, what was the yellow stuff meant to be egg, mash or something else 😕

[i].....something to do with lipase induction so more of the Scottish breakfast was used to replenish glycogen than would be without the evening exercise[/i]

Thats what was kinda going through my mind, along with whether fat in the blood would be re-processed by the liver back to glycogen.
But that sounds a bit simple.

Way I understood it was, blood sugar, sent to the liver becomes glycogen. If theres enough glycogen, then the surplus is stored as good ole fat, visceral or under the skin.

What surprised me was the presence of fat in the blood at all.

I'd have thought that the digestive processes would have converted the fat to a water soluble form for transport around the body - with the conversion back to fat coming into play as it was laid down as "reserves".

quite an eye opener

Yeah solo, I agree. I'd have liked him to go into a little more explanation of the blood fat part. He just did the test, then moved onto another new theory and university.

[i]I'd have thought that the digestive processes would have converted the fat to a water soluble form for transport around the body - with the conversion to fat coming into play as it was laid down as "reserves".[/i]

Apparently the Lipoprotein Lipase assits with making blood fat available for either energy use or for storage.

So, if I'm seeing this correctly, although his activity ( long walk the evening before ) had taken place some time before his 2nd blood test AND after he had eaten that English breakfast for a second time.

The Lipase was still preforming its role to meet a need to provide blood fat for energy or for storage.
To greater effect than on the first occassion when he had eaten the first breakfast without any prior exercise.

rkk01 - Member
What surprised me was the presence of fat in the blood at all.

Tis true, when I worked in a clinical lab we could always tell the patients who hadn't stuck to the "overnight fast" rule - couple of mm thick layer of fat (well lipoprotein really, not 'raw fat') on top of their plasma after spinning down 😕

Blood fat (lipid) is transported in a complex with proteins = lipoproteins,
the LPL enzyme removes the lipid element from the protein element so making it available for uptake and subsequent processing (to glycogen or glucose phosphate) by the liver...

..it's a long time since I did any of this kind of stuff so I'll back away slowly now 😳

I just took the non-responder thing to describe the people whom during the test, didn't, err, show any significant response or imporvement to the exercise they were undertaking.

My understanding of that bit was he was genetically disposed to be a non-responder, as the scientist said he had predicted that before the test started. I presume (but it wasn't clear) based on some sort of test before the exercise regime started.

[i]Blood fat (lipid) is transported in a complex with proteins = lipoproteins,
the LPL enzyme removes the lipid element from the protein element so making it available for uptake and subsequent processing (to glycogen or glucose phosphate) by the liver...

..it's a long time since I did any of this kind of stuff so I'll back away slowly now
[/i]

Yes, I've been reading that.
Might be the basics for you, but I find it to be fascinating stuff.
🙂

[i]My understanding of that bit was he was genetically disposed to be a non-responder, as the scientist said he had predicted that before the test started. I presume (but it wasn't clear) based on some sort of test before the exercise regime started. [/i]

Yes, he is in the non-responder category.
But as for what a non-responder is.
Then it would seem that some folk wont get much from their gym membership.
Of course, the first step was to find the non-responders and then to profile them genetically to see if there was a genetic basis for it.

What still fascinates me is that the presenter exercised the previous evening.
Then sleept, got up the mext morning, had breakfast [u]and[/u] then four hours later, his blood fat was still visibly at a lower in the blood.
This demonstrated for me that the body's processes and systems operate with lag / momentum.
🙂

What still fascinates me is that the presenter exercised the previous evening.
Then sleept, got up the mext morning, had breakfast and then four hours later, his blood fat was still visibly at a lower in the blood.

The exercise induced the LPL enzyme, I assume by that time the blood lipoprotein levels were low(ish) so the enzyme had no substrate to "work" on, when the high fat brekky came in the morning the unused enzyme then has something to act upon.

I reckon if the presenter had pigged out at evening meal the "next morning" effect may not happen.....

...I'll try to remember to do some reading and see what the current opinions on this are, unless there's some further contributions to the thread from the more well informed....

But as for what a non-responder is.

I'm going to try and find the Nottingham group's work, it must be published somewhere, can't recall the chaps name though - guess BBC website may have it in the program credits......

[i]The exercise induced the LPL enzyme, I assume by that time the blood lipoprotein levels were low(ish) so the enzyme had no substrate to "work" on, when the high fat brekky came in the morning the unused enzyme then has something to act upon.

I reckon if the presenter had pigged out at evening meal the "next morning" effect may not happen.....
[/i]

Good point, we weren't told when and what he had for his evening meal.

The LPL works with apolipoprotein to chisel-off the fat from the carrier protein.

I'm viewing this with what that Lustig fella was explaining in that " Sugar, the bitter truth " video iDave posted a few days ago.
How low blood triglicerides and high HDL are considered to indicate that most of the LDL is the low density LDL, which is supposed to be preferred, wrt to the accumilation of arterial plaque.

I'm going to try and find the Nottingham group's work, it must be published somewhere, can't recall the chaps name though - guess BBC website may have it in the program credits......

I've just been looking this up myself. His name is Prof. James Timmons but it looks he works at Birmingham now.
These seem to be the two most pertinent references:

Variability in training-induced skeletal muscle adaptation
J Appl Physiol 110:846-853, 2011. First published 28 October 2010;
James A. Timmons

Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans
James A. Timmons et al
Journal of Applied Physiology June 2010 vol. 108 no. 6 1487-1496

The first one is a short review the second has all the details.

I might have to go order some primers to find out where I am on the response to exercise scale 😉

So does intense exercise also generate LPL whatever it was?

onewheeltoofew - Member

I might have to go order some primers to find out where I am on the response to exercise scale

thinking exactly the same, have a small amount of funding for "miscellaneous PCR method development" that I haven't decided what to do with - now I know 😀

Whaddya reckon, £50 (cash or PP only, no cheques) a sample sound a good price for STWers ??

molgrips - Member
So does intense exercise also generate LPL whatever it was?

Can't remember, sorry 🙁

The enzyme will degrade with "physiological time" so I think the idea may be to perform exercise sufficient to induce the LPL synthesis but not of an intensity to significantly elevate the rate of metabolism & CV activity.
You would also want to stay aerobic as I'm pretty sure once you go anaerobic the enzyme levels & metabolism dramatically alters as the body's main "concern" is then to stabilise carb metabolism rather than regulate blood LipoProtein.
Hence the conventional wisdom that if you want to "burn fat" you need to stay aerobic - so low intensity/high duration...

...As always, I defer to anyone whose information is more current than mine 😉

[i]So does [s]intense[/s] exercise also generate LPL whatever it was? [/i]

On the circumstantial evidence in that TV show, one might be forgiven for thinking it does.

As above, I'd have enjoyed a slightly deeper look at the result they observed wrt his blood tryglycerides, the exercise he undertook and the breakfast he consumed.

Also makes me think that particular Sat-Fats in your diet is desireable

Whaddya reckon, £50 (cash or PP only, no cheques) a sample sound a good price for STWers ??

I'm in, I've got a fantastically quick, easy and cheap protocol for extracting DNA from buccal cells. *kerching* 😉

So does intense exercise also generate LPL whatever it was?

[i]the actual amount used in a given time is much greater so pootling around in the 'fat burning zone' is a waste of precious time. It's really all about getting the body more efficient at recruiting fat as an energy source. Things like the idave diet work because it forces the body to to use more fat as a source of energy as all the processed, readily available carbohydrates have been removed from the diet[/i]

However, once you have [i]turned the corner[/i] wrt to your body reverting from relying on glucose/readily available Carbs, as its primary fuel, to burning fat.
Then [i]pootling around[/i] will burn fat and is sustainable for longer.
Hence I can walk a greater distance that I can run, by design.

Ref the LPL thing. It seems to be quite complicated, with a lot of the reading I've done being related to its role wrt atherosclerosis.
Quite what triggers the production of LPL I can't nail just yet.

However, once you have turned the corner wrt to your body reverting from relying on glucose/readily available Carbs, as its primary fuel, to burning fat.

Now I suspect that how easy it is to turn that corner, and how effective it is, varies from person to person - based on people's iDave stories on here.

varies from person to person

Where people store fat and how quickly they can draw on those stores have been assessed.

Maybe people can be "non-responders" to certain diet/food lyfestyle options too.
I think one of the main messages from the program was everybody is different.
Until the science becomes readily available for people to test and design personalised responsive diet and exercise plans, we all need to self experiment a little.

that Scots bloke recommending the exercise was deffo a responder to pies !

flap_jack - Member
that Scots bloke recommending the exercise was deffo a responder to pies !

Dam you Flap_jack I was just about to say

"If it's that good and easy to do how come the so called expert was a bit of a porker"

Dam you again Flap_jack 😉

you watching it on the iplayer too then ?

Something very fishy about the VO2 max test IMO, I've watched it a few times. Is the x axis HRM ? Wouldn't you expect a reduction as he will be fatigued from the HIIT ? SO if it's the same then it's an improvement ?

Not enough info. Grrr.

After all the threads on here with folk messing with the Tabata protocol then not getting results, letting this loose on the general public will be a disaster.

Where people store fat and how quickly they can draw on those stores have been assessed

I suppose.. people can lose weight more easily than others.. that fat logically must be being burned up..

[i]Now I suspect that how easy it is to turn that corner, and how effective it is, [b]varies from person to person[/b] - based on people's iDave stories on here.[/i]

Couldn't agee more.
Now might we consider why ?.
🙂

Would it be acceptable to expect that most successes were / are enjoyed by those with good adherence and ability to devise a wider range of compliant meal choices.
Over any kind of bio-chemical abnormality ?.
Not withstanding the caveat that the body has its own agenda which does not recognize any prevailing, media promoted, [i]physique[/i] for either men or women.
ie, small stubborn fat deposits that one might really like to banish, but that your body is quite determined to keep a hold on.
Which is a triat common to most of us as a result of our evolutionary inheritence.

[i]Until the science becomes readily available for people to test and [b]design personalised responsive diet and exercise plans[/b], we all need to self experiment a little.[/i]
Theres lots of text out there, but filtering and absorbing the relevant info aint allways easy, I'll grant you.

Ahem, some [i]people[/i] already claim to design a specific, personalized eating and exercise plan, for a fee.

However, in my experience you must be very careful though.
I tried paying for such help and received nothing whatsoever.

Yeah, I did notice, it was a chubby fella who was advising the presenter on HIIT and its proven results.
It can't ever really further the cause when you have over weight lab boffins telling us how we need to get trim.