[Closed] DNA Sequencing, anyone had it done?

Health and Ancestry test of your DNA for £149 (wow).

Pretty amazing when you consider the resources poured into sequencing the first human genome in the 90's.

I was at an IT conference a couple of months ago that said the current cost was around $100 a genome but it would rapidly fall to >$1 with the computing power that's going to be available in the next 10 years.

not got the best reputation...

[url= http://www.bbc.co.uk/news/science-environment-30285581 ]http://www.bbc.co.uk/news/science-environment-30285581[/url]

Pretty amazing when you consider the resources poured into sequencing the first human genome in the 90's.

23andMe aren't doing full sequencing, either RAPD or SNP analysis of a sub-section of genes.

Brian Cox had it done - found out his genes have never left Oldham, Robin Ince found that he came from 300 years of Vicar stock.

I had mine done - both Mitochondrial DNA thus following the female line) and nuclear dna for the paternal line

I share most of my genes with the Sami people of lapland A small amount of saxon and dane on the paternal side and a small amount of French celt on the maternal side - interestingly both sides had the sami people.

So I am the son of the son of a reindeer herder

23andMe is SNP microarray analysis not sequencing. Its more lifestyle analysis but not a diagnostic test.

I've got to send my blood sample to Illumina (world largest manufacturer of DNA sequencers) this month and I'm getting my full genome sequenced at minimum x30 depth.

That costs £1,000's but its a perk for my company ordering £M's from Illumina.

Should be interesting.

Should be interesting.

bet it won't. Go back a few thousand years and you share DNA with pretty much everyone in Western Europe

Aren't we supposed to be 98% banana?

TJ where did you have it done?

I've got a hunch on my lines line.

Depends what info you want to get out of it?

Very easy to interpret it however you want to, also open to a lot of bias due to inbreeding ( not brother and sister just extended family, 2nd cousins etc in small villages /tribes very common) which can really skew the results.

Fascinating from a scientific viewpoint, not really that useful for genealogy.

I was at an IT conference a couple of months ago that said the current cost was around $100 a genome but it would rapidly fall to >$1 with the computing power that's going to be available in the next 10 years.

But getting a skilled bioinformatician to analyse the data will still cost $00s, and storing the data securely another $100 per year.

Tonyg2003, could you contact me, please?

[i]Depends what info you want to get out of it?[/i]

Just enough to get much more expensive health and life insurance 😉

I've heard a few radio articles saying how the ancestry stuff is so inaccurate it's pretty meaningless.

and storing the data securely another $100 per year.

WTF!

Encrypt it and stick it on AWS for about $0.00001 per year more like.

Molpgrips I did think someones sat in a room throwing in the odd howler for fun

'Finnish hey'? How about Saharan subcontinent

So I am the son of the son of [s]a reindeer herder[/s] Santa Claus !

Had a similar thing done on the dog to find out what breeds she is (stray from Battersea). I got the test as a Christmas present and the family had a drunken sweepstake on the results. We were all wrong!

There was a thing on TV about this a while ago, basically you have to pick a specific moment in time, so it may be able to give you a general idea of where your ancestors where at that point in time.

So 5000 years ago, your ancestors may been in Scandinavia, 20000 years ago they were in Northern Africa, but if you take it back to the earliest Home Sapiens, roughly (from memory) about 200,000 years ago? So there was a migration of people fanning out from East Africa.

Same as if you blue eyes, then you will trace back to one person at some point in time that had that first mutation?

Interesting from a genealogical point of view, complete bunkum from a health perspective.

Pretty much Martin.

What I had done (and I don't remember the details exactly ) but it showed % of the genes which where shared with various groups of people - both common ancestors and where those people ended up today. The biggest single % was shared with the sami people. so somewhere after the last ice age as the tribes moved north and west my bunch split off from the main tribe and ended up in the welsh borders. Thoosands and thoosands of years ago. The main tribe ended up herding reindeer on the tundra! Rest of me is basically the usual Germanic tribes IIRC interlevened with the odd touch of marauding viking

Why bunkum from a health point of view?

Specific genes of specific diseases are notifiers of future/current disease.

Why bunkum from a health point of view?

Specific genes of specific diseases are notifiers of future/current disease.

In many cases they only increase the chance by a small percentage, so in isolation it's not a lot of value. Hence the US Medical authority banned them from making claims about this (as the evidence doesn't support it).

There must be some genes, gene combinations that are on/off indicators though. I get that there are loads more that are "maybe this gives you a chance of breast cancer increase by +0.5%

And obviously there's all that stupid science looking for the "gay" gene or whatever.

I work in a clinical genetics department (as the hopefully skilled, but could be more handsomely paid, bioinformatician) and we only really test for Mendelian diseases rather than additive effects (what JackHammer is describing). Whilst the technology to identify changes is pretty good, the interpretation is still very challenging.

Something like the [url= https://www.genomicsengland.co.uk/the-100000-genomes-project/ ]100k Genomes[/url] will hopefully marry up the scale of technology and analysis in the mid term future.

A very good overview of what genetic testing means from a personal health perspective is given in [url= http://www.cureffi.org/2016/01/20/does-this-mean-ill-definitely-get-the-disease/ ]this blog post[/url] for those that are interested.

And 23andMe are best avoided when it comes to healthcare claims as they aren't certified to make any!

http://www.northgene.co.uk/ are our sister-company

Some of the work they do for the Jeremy Kyle show is a bit eye-opening...

Go on..

Onzadog - Member
Aren't we supposed to be 98% banana?

That make me laugh far more than it should. Ta 🙂

Well it costs about $1000 in consumables to sequence a genome (added to the $10M for X10 sequencers, assuming approx 30,000 samples run per year). Obviously less if the manufacturer is running the test. The bioinformatic analysis (not the storage) is the expensive part if you want full curation. Think $3-4K per genome in total.

As geneticist - it will be interesting for me. Not the geneology but the mutation and variant analysis, plus how this is disseminated to the "patient"

There are genes that are on / off indicators but you are already likely to have found out about those genes by already suffering their ill effects. Eg haemophilia, cystic fibrosis, muscular dystrophy. There aren't many genes that are suddenly activated later in life to cause a disease (Huntingdon's, breast cancer - Braca1/2?) which it's going to be useful to you to find out about when doing a 23&me test in your 40's.

There will be other genes which may interact with other genes and environmental factors to increase the chance of something but this is hideously complicated and something we're only just beginning to have a miniscule understanding of.

As an analogy think of a computer program with 50000 lines of code which runs in duplicate with another almost identical program with 50000 lines of code. Each line of code may have some affect or none on the other 99999 lines of code. Each line of code can also be affected by any number of external factors and the affect can change depending on the timing of the external factor. How many different feedback loops could you find in this system?

This makes it incredibly difficult to then conclude that the presence of gene x will increase your chance of disease y by z%.

@tonyg2003 - where do you work? If you can say of course. 🙂

@sboardman - I'd rather not say on a public forum. I can pm you if you wish

Yeah fair enough. I had Huntingdons disease in mind when describing Mendelian diseases (everydays a schoolday).

On a slightly more oblique tangent you've got your siRNA oligos which are in the process of being researched at the moment. Which will allow the silencing of genes and/or the cutting of gene sequences out.

Shirley they aren't doing this sort of research without targets to cut out?

Go on..

Bloody funny though.

@tonyg2003 - totally understand (I am also helpfully vague with employment ;)), mail is in profile.

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