I have a road bike with a titanium Van Nicholas road bike. I have a recurring problem where the rear wheel slips in the frame so the front of the non drive side of the tyre rubs on the frame. This is cured by releasing the quick release and centring the wheel. I am not week and the skewers are being done up tight. Is a better quick release the answer. The wheel is a Cero AR24 although it also did it with the old Ultegra wheels and a shimano quick release. Everything is clean and I have tried roughing up the surface of the frame on the inside of the drop outs so it holds better.
Any Advice.
which of these is it like?

I will have to check later but I think it is the semi-vertical drop out.
Sounds like the dropout may be worn on the axle interface, or the axle may be worn allowing it to move in the dropout.
A semi-vert dropout sounds a little odd on a modern frame.
Pics?
I wonder if the dropouts opened up a bit? As al says - the end of the wheel axle should be snug in the dropout.
I've had an issue in the past where the end of the axle stuck out slightly past the outside of the dropout - you were effectively doing the QR up against the end of the axle not the outside of the dropouts.
This happens on my VN as well unless I do up the QR extremely tight. Vertical Dropout. Is there an easy cure?
Push the wheel forward as muh as possible when fitting it (on both sides)?
This question has been asked before, and I've had a friend who suffered from it with a front wheel on a CX bike under heavy (disc) braking.
Get yourself a DT Swiss RWS skewer - you can fasten them up incredibly tight and, from my friend's experience anyway, once fastened, the wheel will stay put!
Good luck.
Ti won't deform much under load, so the QR won't dig in as well as it might on an aluminium or even steel dropout.
Shimano skewer, done up really ****ing tight, with everything clean and seated properly is your best bet.
Get yourself a beefy skewer (shimano ones are good too) and do it up really tight. The wheel won't move. This used to an issue on horizontal dropouts (my nice old 653 frame is horizontal) but much less common now.
Get yourself a DT Swiss RWS skewer – you can fasten them up incredibly tight and, from my friend’s experience anyway, once fastened, the wheel will stay put!
Was going to suggest one of these, I used one on a SS with trackends which pretty much stopped any slipping
As I see it, wheel shouldn't be able to slip in a vertical dropout - "can't" move fore/aft and there's 30-40 kilos holding the frame down onto the axle
I also think the dropout may have spread a bit, or there's something weird about the axle
where does the tyre rub, seatstay (ie mostly vertical slip with a bit of horiz) or chainstay (horizontal slip) ?