721 is a harder rim- not so much stronger, exactly, but they definitely resist dents better so if you’re in the habit of running too-low pressures then Flows are much more likely to give you gyp. I’ve pretty much ruined my Ex for tubeless in just a few rides, it still works fine but it’s got a big flat spot and won’t hold air any more. It did take a big ol’ hit to do it though, but I’m not delighted about it. Still, it’s still fine for tubes so I suppose I could say it’s still ahead of the 721.
The Flow I had on there before lasted 3 years of constant use, first on a big trail bike then onto the dh bike, it finally cracked at the valve hole and tbh I can’t fault it at all for that, one of my old 721s crached in multiple places under much the same treatment.
Bottom line is, yes they are less tough but they’re still very sturdy, it takes a proper kicking to damage them badly… But, they’re easier to ding.