Giant’s Defy range are excellent bikes. I bought one earlier this year after searching long and hard for something that suited my needs. I’ve tried many road bikes in the past and never really got on with them, but the Defy really is a gem. It’s probably that it’s subtly more upright than a full on arse up head down position, the frame has been hydroformed in such a way to make it more forgiving, and the 25c tyres that all add up. But to me, an avid mtber of many many years who never got on with road bikes, I love it!
And if not a Defy, well check out the Specialized Allez models for something similar, though IMO not as polished.
And trust me, you will end up wearing Lycra. It just makes sense!