5.1's made of cheese! are you mad?
Julesg007, the best bit of advice I can give is that get the wheels built up by a reputable wheel builder, which ever set you go for. All the strength of the wheel is in the build and not in the rim, a badly built or uneven tentioned wheel will soon break / dent or buckle regardless of make / model. I have been running 5.1's on 440FR hubs with DT Revolution spokes for 3 years now, Cwm Carn DH to Skyline any anything in between. I have not had to retrue them once, I only ever send them in to my LBS for tention check every 6 months or so.
The 4.2's will be fine for Cross Mountain / Trail Centre use if built up well, just remember that tyre size will be more limited. If you go for factory built wheels get them retentioned befor any use and they should last.