A problem I had with the sliders on my Konas is that the dropout itself ISN’T vertical, so the wheel can pull forward and out under high chain loads. Even with a nutted axle! And that can hurt, it also makes you look stupid if you’re setting off from the lights with a queue of rush-hour traffic behind you…
The reason for the slight angle forwards is so that you can remove the wheel without forcing the chain off.
If I were having a custom frame made for SS and disc brake, I’d be looking for a donor Inbred to re-use it’s cheap-but-brilliantly simple “slot dropouts” aka track-ends. Moving the caliper once in a while isn’t a great trauma – how often do you envisage adjusting the chain tension? I adjust my PC870’s about 3 times over their lives (which must be 4 to 6 months at a guess).