It is really a bit hit and miss, I take a 50 in sidi they look a bit pointy but are ok as the upper is soft and adapts to the foot, Specialized I am normally 49, but they don’t really have any give in the uppers, so the new 2fo cliplite have a last that cuts in on my big toe, gets quite annoying after a while. I find lake shoes to be a good size and go up to sizes for fully grown men, they have a good wide toebox in standard and do wide fittings as well, however you have to go up the range to get a decent shoe IMO the cheaper ones are not good at all.
Its an odd thing but with the advent of internet shopping I have gone up a size or two over the past 5 years, just due to being able to buy shoes that fit and not spend my life cramped into badly fitting shoes. But is does mean having to order shoes to try and and send back if they are not right, a process that is available to most in shops but not for the larger footed gentleman.