Coincidence this as I was just about to post something similar.
Have been using mine on my Mac for a year now with great success, but this week had to port everything over to a new work PC. I managed to transfer all my files across and get the thing synced with iTunes. I had a few problems with getting the email to work properly and now, somehow, the whole thing has fallen over. Having done a combination of hard reset on the phone and reinstalling iTunes, I get an Error 0x800000A message every time I connect.
**** PCs, I hate them! Everything is always 10 times harder than it needs to be. If it were not for the fact that I need a PC for my new job (seven months out, finally back in the saddle!) I would throw the thing in the bin!