I can only add – on bikes that are subject to pedal strikes – ever few mm here and there adds up to an important log / rock that you miss (and maybe saves you a trip to A+E).
So what worked for me:
– shorter cranks
– more fork and shock pressure (not ideal)
– thinking ahead
– bigger tyres (think rubber queens)
– loose weight
– get a new frame
Ok – I never got as far as the last 2.
In answer to your opening Q- yes you will probably notice it. It might be better or worse for pedalling depending on what you’re used to.