Either an air blockage somewhere in the pipework, or the worst outlook, a pipe blocked with lots of gunge.
It is usually the return pipes that have the problem. Air in the system can be really easy, or a right pain to get out. Firstly, turn off all other radiators, with the heating on. This should then give more pressure to the one faulty rad, and , hopefully, push out the air bubble.
If it is a blocked pipe, then a dose of central heating cleaner in one of the rads, then leave it for 2 weeks, then a drain and flush out. This should clear any blockages.
Try turning off all other rads first to see if it is an easily removed air lock.
Alan.