Nutritional Ketosis for Weight Management and Reversal of Metabolic Syndrome
Compelling evidence exists for the use of nutritional ketosis for the management of weight and the components of metabolic syndrome. Through the utilization of alternative fuel sources, namely ketones, we can capitalize on the antagonistic relationship of high glucagon and low insulin levels that promote breakdown of fat for fuel, sparing of glycogen in muscles, and de novo gluconeogenesis as needed. Further research is needed into long-term adherence and practicality of VLCKD, but the current results are promising for weight management, lipid profiles, and insulin sensitivity
s a species, we have metabolic flexibility with the capability to rely on alternative fuel sources for energy. Humans are not dependent on exogenous sources of glucose for optimal function; rather, we have evolved over millennia to adjust to changing conditions and adapt to both scarcity and abundance. As Dr. Randle explained in the Lancet in 1963, “Substrate metabolism in the normal human body is flexible. Our bodies have evolved to utilize different fuel sources depending on their availability.”7
Humans have evolved with the capacity for metabolic flexibility and the ability to use ketones for fuel. During states of low dietary carbohydrate intake, insulin levels remain low and ketogenesis takes place. These conditions promote breakdown of excess fat stores, sparing of lean muscle, and improvement in insulin sensitivity.
Original research into a ketogenic diet began in the early 1900s as a way to manage epilepsy and minimize seizure activity. By inducing ketosis, patients had mitigation of seizure activity and improvements in cognitive function, highlighting the capacity for ketones to provide energy to the brain.15 From the 1960s onwards, very low carbohydrate ketogenic diets (VLCKD) have become more commonly known as a methods for obesity treatment. Recent work over the last few decades has provided evidence for the therapeutic potential of ketogenic diets in many pathological conditions, including diabetes, PCOS, acne, neurologic diseases (epilepsy, Alzheimer’s, CVA), cancer, and the amelioration of respiratory and cardiovascular disease risk factors.15 The possibility that modifying food intake can reduce or eliminate need for medications, which often carry significant side effects, calls for serious investigation. Dietary carbohydrate intake has been studied with variable findings, which is often due to lack of standardization of carbohydrate intake and inability to confirm ketosis without checking blood ketone levels.
TJ said:
Ketosis is the presence of excessive ketones in the body caused by starvation, fasting, alcohol binging and uncontrolled diabetes. Ketoacidocis is when the levels are so high as to overwhelm homeostasis and cause the blood PH to alter. The first is harmful if prolonged, the second dangerous and life threatening. Ketosis is the first stage on the way to ketoacidosis.
Tj can you point me in the direction to claims that ketosis is the first stage on the way to ketoacidosis
Tj can you point me in the direction to claims that ketosis is the first stage on the way to ketoacidosis
It isn’t they’re similarities but it’s not first stage and it’s not Ketoacidosis.
TJ you really need to calm down in threads like this.
I can’t use energy drinks, the number of pee stops gets ridiculous! Annoying as they seem the simplest way to combine hydration and fueling…
I rarely need to stop to pee. Just about the only thing in which gifted with truly world class ability is sweating. I sweat a lot, consequently I can ride hard in just about any climate; not needing to pee is a side benefit 🙂
I've had a good week. About a kg down, quite possibly because I've only done one ride.
Wait, you've LOST a kg because you've only had one ride? Are you trying to imply that by not riding you've been able to restrict calories more?
I seemed to gain 2kg on my holidays, but yeah, there were a few beers and bags of crisps (and one chippy) but also two big, hard gravel rides where I though for sure I'd be in a big calorie deficit...
Wait, you’ve LOST a kg because you’ve only had one ride? Are you trying to imply that by not riding you’ve been able to restrict calories more?
Yes. I've stuck to the diet really well.
I have done a bit of walking and I worked up a hell of a sweat sawing up a 8x4 sheet of 20mm ply into shelves the other day. Taht was like an hour long KB workout.
