For wheels, you need to provide kinetic energy to move them forward and rotational energy to make them go round. For the frame it is just kinetic energy.
KE = 0.5 m*v*v
Where m is mass and v is velocity.
For wheels, there is rotational energy
RE = 0.5 I*w*w
Where I is the moment of inertia and w the angular velocity.
I ALL the mass is at the rim (it isnt) the I = m*r*r and since v=r*w you get the same energy for rotation and movement.
In fact this ignores hub weight so the ratio is less than a half.
Not only that, at constant velocity, the proportio n of total energy in the wheels (compared with the 70kg lump above them) is negligible.
There are small benefits in accelerations uphill. But they are just that, small.