I have used a Rohloff on four different frames. Two were Thorn frames and these were the easiest to set up because of the Rohloff specific dropouts. They are probably the best dropouts out there for the job but you have to be happy with an EBB. Most Thorn frames are for 26 inch wheels which is something I wanted when I bought the first bike but would now not choose. They are also mainly non disk.
I then tried a made for me Woodrup. It was a beautifully made bike but not quite what I wanted. Anyway, it had sliding dropouts. These worked well but having chunks off aluminium bolted onto a beautiful steel frame did seem a bit odd and given that they were kind of cantilevered out backwards a long way, felt a bit vulnerable to me. But I guess it is the way many bikes are built and must be strong enough. The advantage is that your BB stays set and you can change dropouts for SS, etc.
The hub now lives on a Surly Troll. Possibly my favourite Rohloff frame so far. I use a tugnut to tension the chain, it has disk fittings (I’m still on Vees) and the rest of the frame suits my uses (general purpose commuter, tourer). The downsides is that wheel removal isn’t as easy as with the Rohloff specific dropouts and I had to change the type of OEM plate on the hub. You also have to adjust the brakes when tensioning the chain too. But the dropouts are solid and simple and it works well. If I wasn’t so lazy I would have rebuilt the wheels and bought an Ogre frame instead as I now feel that bigger wheels are better.
So in short, your main choices are based around chain tensioning. There are always compromises and each method has its advantages. If I was buying a new frame for my ‘hoff today I’d buy a Tumbleweed. You won’t find one secondhand though.