If its the underground you want then I’d go Hillingdon or Ickenham, personally I’d avoid Ruislip and Uxbridge as these are both Shopping centres and may be busy. Depends where you’re going really if the Central line is more convenient than the Metropolitan then Perivale would be a good bet.
If you’d prefer rail then take a look at Denham (into Marylebone), Hayes & Harlington or West Drayton (into Paddington). Hayes will have the greatest frequency of trains as it is also served by Heathrow connect services but it is the furthest from the M40 (10-15mins depending on traffic).