I’ve got a home brew ‘multi-wheel’ commuter, based on a 26in MTB frame but can take 700x35c, 650bx~47c, or 26x as big as you like. It’s the result of a decade’s worth of trying different stuff from a 700x23c drop bar SS road bike, through tourers, converted MTB and everything in between. It’s still not perfect but its 90% of the way there!
It spends 90% of it’s time running on 26×1.75 Paselas, comfy, good for hauling loads, which this bike does a lot of, robust, ‘fast enough’ for urban commuting.
I actually prefer the smaller wheels round town from a handling pov, especially at slow speeds, with a full load or with the trailer on the back, it’s just a lot easier to manoeuvre than when it has bigger wheels in it,a nd the extra rubber width seems to add some stability too so its a kind of win-win. Also drops the BB a bit which is very useful for stop/start riding with heavy loads as easier to stick a foot down.
Depends on your commute though and circumstances, if it’s a 15+mile A road blast with a saddle bag you’ll be wanting a very different setup to someone hauling full panniers around in town, and if I have to travel further I often take another bike entirely instead!