Depends what you consider the cons to be.
If it’s difficulty in getting the beads to pop in place, then all you can do is try as it’s as much to do with variances in rim circumference as it is the tyre. So if you’ve already got the rims sealed with tape, just try with some soapy water. If you can’t get them to seat with just a track-pump then it’s probably not worth the hassle.
Other issue is potentially fragile sidewalls (compared to UST), meaning you’ll be hesitant to run them at lower pressure, hence you’re not getting much benefit over running tubes.
I’ve run Conti Protection tyres tubeless. Needed sealant, but they sealed fine from new – only needed to top up air once a month.