There’s some info here already.
http://singletrackworld.com/forum/topic/650b-and-other-plus-sizes-if-you-like-rim-tyre-frame-fork-combinations
I’m running wtb scraper rims(45mm wide) on hope hubs currently. My Pikes are normal 29er and run 3.0 tyres just fine, you would have to take accurate measurements of the frame to know what you can get away with on the rear, most of the time it seems to be 2.8s that work, on scraper rims you’re looking at 72mm ish.
Another thing to take into account is chain clearance, you’ll probably be forced to go 1X10/11 or the chain will rub on tyre.
Oh and fwiw it’s fun on a hardtail, im about to venture into full suss + 🙂