Wheels would be first to go.
Conti GP4000s tyres are light/sensible choice. 23mm or 25mm is a good argument as supposedly 25mm rolls better and is marginaly more comfortable, but is less aero and weighs marginaly more.
Conti supersonic inertubes are 50g each and dont lose air anywhere near as quickly as their latex equivalents, just don’t try pumping up with a hand pump as the valves are fragile.
Bar+Stem, is a comfort/feeling/fit/controll thing, don’t get hung up on weight as some light bars flex alarmingly, but some heavier bas are comfortable. Like saddles, saving weight here is a false economy.
Chainsets, 3rd party ones tend to be the lighter, eg FSA SL-K.
My Cannondale R500 (bottom of the cnnondale range) now has a 2nd hand DA groupset, FSA SL-K chainset, R-550 wheels, Conti GP4000 tyres & SS tubes and some bontranger carbon bars (medium reach but shallow drops as I like a longer/lower stem so didn’t want the drops/hoods to be miles away from the tops. Buying all that 2nd hand has been pretty cheep, whole bikes probably under £700!
Next on the list are some new wheels, probably fairly heavy handbuilts (open pro, 32spokes, average hubs) so not saving any weight just replaceing the current ones and adding some stiffness. And probably a new set of finishing kit as it’s a bit of a mish mash of brands and the bars aren’t as nice as I thought they would be.