Within two hours of Newcastle (keeping vaguely to the speed limits) you won’t get much further than GT/Innerleithen. You certainly won’t get to Ae, Drumlanrig, Mabie or any of the other places. Whinlatter is pushing it too.
Hamsterley is more local (1hour) and is suprisingly good now that they’ve done all the new bits.
Kielder (just over an hour) is a nice ride in good weather but not very technical and more suited to long rides than quick thrills.
Both Glentress and Innerliethen will be good fun too. There is more variety and options at glentress as you can mix the blu black and red up (Innerliethen is pretty much up then down with only a coupl of options).
I personally wouldn’t drive to Dalby as I think it is a bit rubbish.
I also wouldn’t drive to Whinlatter as, while the trails are good, there are only about 15 miles of way marked stuff.