I run Hope 20Five with Surly Knard 41c tyres for wet weather commuting and Kinesis Racelight Disc with Conti GP 4 Season 28c on dry days.
While both are of comparable quality and cost, the latter wheelset really perks things up on my Straggler (wouldn’t be hard to be honest!). With the same discs and cassettes, there’s c.900g between them – about 500g in the tyres and 400g in the wheels and skewers.
Because of the mudguards and wheel slippage in the dropouts under power, I run the Kinesis wheels closer to the frame. This means that I have to make slight adjustments to the rear disc caliper when changing wheels, but it’s otherwise an easy swap between the two.